期刊
TRANSLATIONAL PSYCHIATRY
卷 3, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/tp.2013.81
关键词
addiction; body mass index; nicotine dependence; obesity; smoking
类别
资金
- NIH [R01-DA017932, R01-DA022522]
- European Commission's Sixth Framework Programme, Integrated Project GENADDICT [LSHM-CT-2004-005166]
- European Commission's Seventh Framework Program [HEALTH-F4-2007-201413]
- [FP7-PEOPLE-2009-IAPP 251592]
- MRC [G0800675, G0600329] Funding Source: UKRI
- Chief Scientist Office [ETM/75, ETM/137, CZB/4/540] Funding Source: researchfish
- Medical Research Council [G0600329, G0800675] Funding Source: researchfish
Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked per day (CPD) in an Icelandic sample (N = 34 216 smokers). Combined according to their effect on BMI, the SNPs correlate with both SI (r = 0.019, P = 0.00054) and CPD (r = 0.032, P = 8.0 x 10(-7)). These findings replicate in a second large data set (N = 127 274, thereof 76 242 smokers) for both SI (P = 1.2 x 10(-5)) and CPD (P = 9.3 x 10(-5)). Notably, the variant most strongly associated with BMI (rs1558902-A in FTO) did not associate with smoking behavior. The association with smoking behavior is not due to the effect of the SNPs on BMI. Our results strongly point to a common biological basis of the regulation of our appetite for tobacco and food, and thus the vulnerability to nicotine addiction and obesity.
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