期刊
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
卷 96, 期 7, 页码 1064-1074出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/02772248.2015.1005091
关键词
fecundity; propylparaben; Drosophila melanogaster; lifespan
资金
- Natural Science Foundation of Shaanxi Province, China [2012JQ3012]
- Fundamental Research Funds for the Central Universities [GK201402026]
Parabensare are widely used as preservatives in cosmetics, foods and pharmaceutical products. Although parabens have generally been considered safe, several studies have cautioned that parabens have estrogenic or endocrine-disrupting properties. With the present study, the effects of four concentrations of propylparabens (200, 500, 1000, and 2000 mg L-1) on fecundity, development and the lifespan of Drosophila melanogaster have been investigated. Decreased daily mean egg production was found in all exposure groups. In addition, the 100 mg L-1 treatment significantly shortened egg-to-prepupa time and extended flies lifespan, consistent with a significant reduction in malonyldialdehyde (MDA) level and an increase in superoxide dismutase (SOD) activities. The 200 mg L-1 treatment prolonged egg-to-prepupa time and decreased flies lifespan significantly, being consistent with a significant increase in MDA level and reduction in SOD activities.
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