期刊
PATHOGENS AND DISEASE
卷 72, 期 3, 页码 167-173出版社
OXFORD UNIV PRESS
DOI: 10.1111/2049-632X.12199
关键词
HIV; tuberculosis; dengue; viruses
资金
- National Institutes of Mental Health [MH096625]
- Public Health Research Institute (PHRI)
Despite significant advances in microbiology and molecular biology over the last decades, several infectious diseases remain global concerns, resulting in the death of millions of people worldwide each year. According to the Center for Disease Control (CDC) in 2012, there were 34 million people infected with HIV, 8.7 million new cases of tuberculosis, 500 million cases of hepatitis, and 50-100 million people infected with dengue. Several of these pathogens, despite high incidence, do not have reliable clinical detection methods. New or improved protocols have been generated to enhance detection and quantitation of several pathogens using high-end microscopy (light, confocal, and STORM microscopy) and imaging software. In the current manuscript, we discuss these approaches and the theories behind these methodologies. Thus, advances in imaging techniques will open new possibilities to discover therapeutic interventions to reduce or eliminate the devastating consequences of infectious diseases.
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