期刊
PATHOGENS AND DISEASE
卷 68, 期 3, 页码 105-115出版社
OXFORD UNIV PRESS
DOI: 10.1111/2049-632X.12054
关键词
antigen-presenting cells; dendritic cells; macrophages; B cells; ectromelia virus; mousepox
资金
- Ministry of Science and Higher Education in Warsaw [2 PO5A 050 30]
- National Science Center in Krakow [2012/05/D/NZ6/02916]
- [0851/3]
During mousepox in resistant (C57BL/6) or susceptible (BALB/c) strains of mice, stimulation of Th1 or Th2 cytokine immune response, respectively, is observed. Because mechanisms of different polarization of T cells remain elusive, in this study, we quantitatively assessed the phenotype of antigen-presenting cells (APCs) involved in ectromelia virus (ECTV) antigen presentation and cluster formation with effector cells in secondary lymphoid organs of BALB/c and C57BL/6 mice. We showed that both strains of mice display similar dynamics and kinetics of viral antigen presentation by CD11c(+), CD11b(+), and CD19(+) cells. CD11c(+) and CD11b(+) cells highly participated in viral antigen presentation during all stages of mousepox, whereas CD19(+) cells presented viral peptides later in infection. The main population of dendritic cells (DCs) engaged in ECTV antigen presentation and cell junction formation with effector cells was a population of myeloid CD11b(+) DCs (mDCs). We suggest that, on the one hand, ECTV may differentially affect the functions of APCs depending on the strain of mice. On the other hand, we suggest that some types of APCs, such as mDCs or other DCs subsets, have different abilities to direct the shape of immune response depending on the host resistance to mousepox.
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