期刊
NUCLEUS
卷 5, 期 3, 页码 224-236出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/nucl.29347
关键词
transcription; RNA Polymerase II; Serine 2; Bur1; Ctk1; Cdk9; Cdk12; P-TEFb; elongation; C. elegans
类别
资金
- NIGMS NIH HHS [R01 GM101040] Funding Source: Medline
The transition between initiation and productive elongation during RNA Polymerase II (Pol II) transcription is a well-appreciated point of regulation across many eukaryotes. Elongating Pol II is modified by phosphorylation of serine 2 (Ser2) on its carboxy terminal domain (CTD) by two kinases, Bur1/Ctk1 in yeast and Cdk9/Cdk12 in metazoans. Here, we discuss the roles and regulation of these kinases and their relationship to Pol II elongation control, and focus on recent data from work in C. elegans that point out gaps in our current understand of transcription elongation.
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