期刊
NUCLEUS
卷 4, 期 5, 页码 379-389出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/nucl.26394
关键词
nuclear envelope; transcriptional regulation; telomeres; heterochromatin; nuclear pore complex
类别
资金
- Swedish Cancer Society
- Swedish Research council
- National Science Foundation [0744945]
- Direct For Biological Sciences
- Division Of Integrative Organismal Sys [0744945] Funding Source: National Science Foundation
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1051962] Funding Source: National Science Foundation
The spatial organization of the genome inside the nucleus affects many nuclear processes, such as DNA replication, DNA repair and gene transcription. In metazoans, the nuclear periphery harbors mainly repressed genes that associate with the nuclear lamina. This review discusses how peripheral positioning is connected to transcriptional regulation in yeasts. Tethering of reporter genes to the nuclear envelope was found to result in transcriptional silencing. Similarly, repression of the silent mating type loci and subtelomeric genes is influenced by their position close to the nuclear envelope. In contrast, active genes are bound by nucleoporins and inducible genes associate with the nuclear pore complex upon activation. Taken together, these results portray the nuclear envelope as a platform for transcriptional regulation, both through activation at nuclear pores and silencing at the nuclear envelope.
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