期刊
NUCLEUS
卷 1, 期 4, 页码 332-336出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/nucl.1.4.12109
关键词
plant immunity; nucleoporins; nucleocytoplasmic trafficking; snc1; mos
类别
资金
- Alexander von Humboldt Foundation
- Le Fonds Quebecois de la Recherche sur la Nature et les Technologies
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- NSERC
- Michael Smith Laboratories (MSL)
- Canadian Foundation for Innovation (CFI)
- DFG [SFB 670]
- IMPRS
Controlled nucleocytoplasmic trafficking is an important feature for fine-tuning signaling pathways in eukaryotic organisms. Nuclear pore complexes (NPCs) composed of nucleoporin proteins (Nups) are essential for the exchange of macromolecules across the nuclear envelope. A recent genetic screen in our laboratory identified a partial loss-of-function mutation in Arabidopsis MOS7/Nup88 that causes defects in basal immunity, Resistance (R) protein-mediated defense and systemic acquired resistance. In Drosophila and mammalian cells, exportin-mediated nuclear export of activated Rel/NF kappa B transcription factors is enhanced in nup88 mutants resulting in immune response failure. Consistent with Nup88 promoting nuclear retention of NF kappa B, our functional analyses revealed that MOS7/Nup88 is required for appropriate nuclear accumulation of the autoactivated R protein snc1, as well as the key immune regulators EDS1 and NPR1. These results suggest that controlling the nuclear concentrations of specific immune regulators is fundamental for defining defense outputs.
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