期刊
NANOSCALE RESEARCH LETTERS
卷 9, 期 -, 页码 1-8出版社
SPRINGEROPEN
DOI: 10.1186/1556-276X-9-324
关键词
Dielectrophoresis; Microparticle assembly; Surface-enhanced Raman spectroscopy
资金
- National Science Council of Taiwan [NSC 102-2221-E-492 -001 -MY2, NSC 102-2633-E-168-001, NSC 101-2218-E-492 -002]
Dielectrophoresis (DEP) has been widely used to manipulate, separate, and concentrate microscale particles. Unfortunately, DEP force is difficult to be used in regard to the manipulation of nanoscale molecules/particles. For manipulation of 50- to 100-nm particles, the electrical field strength must be higher than 3 x 10(6) V/m, and with a low applied voltage of 10 Vp-p, the electrode gap needs to be reduced to submicrons. Our research consists of a novel and simple approach, using a several tens micrometers scale electrode (low cost and easy to fabricate) to generate a dielectrophoretic microparticle assembly to form nanogaps with a locally amplified alternating current (AC) electric field gradient, which is used to rapidly trap nanocolloids. The results show that the amplified DEP force could effectively trap 20-nm colloids in the nanogaps between the 5-mu m particle aggregates. The concentration factor at the local detection region was shown to be approximately 5 orders of magnitude higher than the bulk solution. This approach was also successfully used in bead-based surface-enhanced Raman spectroscopy (SERS) for the rapid identification of bacteria from diluted blood.
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