期刊
NANOSCALE RESEARCH LETTERS
卷 8, 期 -, 页码 -出版社
SPRINGER
DOI: 10.1186/1556-276X-8-122
关键词
Carbon dots; Biocompatibility; Toxicity
资金
- National Natural Science Foundation of China [81101169, 20803040]
- Chinese 973 Project [2010CB933901]
- New Century Excellent Talent of Ministry of Education of China [NCET-08-0350]
- Special Infection Diseases Key Project of China [2009ZX10004-311]
- Shanghai Science and Technology Fund [1052nm04100, 072112006-6]
Photoluminescent carbon dots (C-dots) were prepared using the improved nitric acid oxidation method. The C-dots were characterized by tapping-mode atomic force microscopy, and UV-vis absorption spectroscopy. The C-dots were subjected to systematic safety evaluation via acute toxicity, subacute toxicity, and genotoxicity experiments (including mouse bone marrow micronuclear test and Salmonella typhimurium mutagenicity test). The results showed that the C-dots were successfully prepared with good stability, high dispersibility, and water solubility. At all studied C-dot dosages, no significant toxic effect, i.e., no abnormality or lesion, was observed in the organs of the animals. Therefore, the C-dots are non-toxic to mice under any dose and have potential use in fluorescence imaging in vivo, tumor cell tracking, and others.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据