期刊
MEDICAL SCIENCE MONITOR
卷 19, 期 -, 页码 681-689出版社
INT SCIENTIFIC INFORMATION, INC
DOI: 10.12659/MSM.889110
关键词
cortisol; Alzheimer's disease; depression; cognitive impairment
资金
- Ministry of Education, Youth and Sports [MSM0021620849]
- Charles University in Prague [PRVOUK-P26/LF1/4]
- Grant Agency of Charles University [41310]
- General Teaching Hospital in Prague, Czech Republic [MH CZ - DRO VFN64165]
Background: Cortisol is presumed to be a risk factor for stress-and age-related disorders, such as depressive disorder and Alzheimer's disease (AD). The aim of this study was to investigate the association of plasma cortisol concentration with AD in presence or absence of comorbid depressive symptoms. Material/Methods: Plasma cortisol concentration was measured in 80 AD patients (35 of them with depressive symptoms), 27 elderly depressive patients without AD, and 37 elderly controls. Results: Compared to controls, a significant increase of mean plasma cortisol was found in AD patients but not in depressive patients. Plasma cortisol was positively correlated with cognitive impairment in AD patients. We confirmed a U-shaped association between plasma cortisol and major depression and a linear association between plasma cortisol and AD without depressive symptoms. Significantly increased relative risk of disease in people with high plasma cortisol was found for AD with depressive symptoms and for AD with mild dementia. Conclusions: Plasma cortisol reflects the degree of cognitive impairment in AD rather than the severity of comorbid depression. We confirmed that both hypercortisolemia and hypocortisolemia are associated with depressive disorder. Significant association between high plasma cortisol and AD was found, supporting the use of high plasma cortisol as a component of a panel of biochemical markers for AD with depressive symptoms as well as AD in the early stage of dementia development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据