相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。S-Adenosyl-L-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells
Tsang-Pai Liu et al.
ANTI-CANCER DRUGS (2015)
Entinostat, a novel histone deacetylase inhibitor is active in B-cell lymphoma and enhances the anti-tumour activity of rituximab and chemotherapy agents
Sarah Frys et al.
BRITISH JOURNAL OF HAEMATOLOGY (2015)
ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat
Simone Meidhof et al.
EMBO MOLECULAR MEDICINE (2015)
Histone deacetylase inhibitor-polymer conjugate nanoparticles for acid-responsive drug delivery
Iza Denis et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
A Novel Cell-Permeable, Selective, and Noncompetitive Inhibitor of KAT3 Histone Acetyltransferases from a Combined Molecular Pruning/Classical Isosterism Approach
Ciro Milite et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Regulation of Wnt Signaling Target Gene Expression by the Histone Methyltransferase DOT1L
Garrett S. Gibbons et al.
ACS CHEMICAL BIOLOGY (2015)
Phase 1 Study of Oral Abexinostat, a Histone Deacetylase Inhibitor, in Combination With Doxorubicin in Patients With Metastatic Sarcoma
Edwin Choy et al.
CANCER (2015)
Overexpression of G9a and MCM7 in oesophageal squamous cell carcinoma is associated with poor prognosis
Xinwen Zhong et al.
HISTOPATHOLOGY (2015)
Autophagy Induction by Histone Deacetylase Inhibitors Inhibits HIV Type 1
Grant R. Campbell et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Histone Deacetylase Inhibition Attenuates Cardiac Hypertrophy and Fibrosis through Acetylation of Mineralocorticoid Receptor in Spontaneously Hypertensive Rats
Seol-Hee Kang et al.
MOLECULAR PHARMACOLOGY (2015)
Garcinol, an Acetyltransferase Inhibitor, Suppresses Proliferation of Breast Cancer Cell Line MCF-7 Promoted by 17 beta-Estradiol
Xia Ye et al.
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2014)
Non-radioactive Protein Lysine Methyltransferase Microplate Assay Based on Reading Domains
Srikanth Kudithipudi et al.
CHEMMEDCHEM (2014)
A Cell-Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1
Rachel Schiller et al.
CHEMMEDCHEM (2014)
The methyltransferase G9a regulates HoxA9-dependent transcription in AML
Bernhard Lehnertz et al.
GENES & DEVELOPMENT (2014)
Sumoylated Human Histone H4 Prevents Chromatin Compaction by Inhibiting Long-range Internucleosomal Interactions
Abhinav Dhall et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation
Frann Antignano et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Histone acetyltransferase inhibitor II induces apoptosis in glioma cell lines via the p53 signaling pathway
Li-Xiao Xu et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2014)
The Hypoxia-Inducible Epigenetic Regulators Jmjd1a and G9a Provide a Mechanistic Link between Angiogenesis and Tumor Growth
Jun Ueda et al.
MOLECULAR AND CELLULAR BIOLOGY (2014)
The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis
Kuo-Tai Hua et al.
MOLECULAR CANCER (2014)
Inhibition of G9a induces DUSP4-dependent autophagic cell death in head and neck squamous cell carcinoma
Kai-Chun Li et al.
MOLECULAR CANCER (2014)
Euchromatic histone methyltransferase 2 inhibitor, BIX-01294, sensitizes human promyelocytic leukemia HL-60 and NB4 cells to growth inhibition and differentiation
Jurate Savickiene et al.
LEUKEMIA RESEARCH (2014)
Inhibition of demethylases by GSK-J1/J4
Bo Heinemann et al.
NATURE (2014)
Inhibition of H3K9 Methyltransferase G9a Repressed Cell Proliferation and Induced Autophagy in Neuroblastoma Cells
Xiao-Xue Ke et al.
PLOS ONE (2014)
C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe
Takahiro Oike et al.
RADIOTHERAPY AND ONCOLOGY (2014)
Epigenetic regulation in cancer progression
Eva Baxter et al.
CELL AND BIOSCIENCE (2014)
Current and upcoming approaches to exploit the reversibility of epigenetic mutations in breast cancer
Fahimeh Falahi et al.
BREAST CANCER RESEARCH (2014)
BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production
Yunha Kim et al.
AUTOPHAGY (2013)
The Histone H3 Methyltransferase G9A Epigenetically Activates the Serine-Glycine Synthesis Pathway to Sustain Cancer Cell Survival and Proliferation
Jane Ding et al.
CELL METABOLISM (2013)
Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity
Takayoshi Suzuki et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP
Feng Liu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Epigenetic Regulation of Autophagy by the Methyltransferase G9a
Amaia Artal-Martinez de Narvajas et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia
T. Holmlund et al.
LEUKEMIA (2013)
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Jianjiong Gao et al.
SCIENCE SIGNALING (2013)
A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth
Lei Wang et al.
NATURE COMMUNICATIONS (2013)
Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines
Sergiy Konovalov et al.
JOURNAL OF OVARIAN RESEARCH (2013)
Protein arginine methyltransferases and cancer
Yanzhong Yang et al.
NATURE REVIEWS CANCER (2013)
mTOR Signaling in Growth Control and Disease
Mathieu Laplante et al.
CELL (2012)
BIX-01294 treatment blocks cell proliferation, migration and contractility in ovine foetal pulmonary arterial smooth muscle cells
Q. Yang et al.
CELL PROLIFERATION (2012)
G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer
Chenfang Dong et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases
Nathan R. Rose et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact
Joshua C. Black et al.
MOLECULAR CELL (2012)
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
Tino Schenk et al.
NATURE MEDICINE (2012)
Chromatin and Genome Organization in Reprogramming
Alva Biran et al.
STEM CELLS (2012)
The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
Ethan Cerami et al.
CANCER DISCOVERY (2012)
Involvement of MyoD and c-myb in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene
Wei Jin et al.
BREAST CANCER RESEARCH AND TREATMENT (2011)
Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties
Jing Wang et al.
CANCER RESEARCH (2011)
Regulation of chromatin by histone modifications
Andrew J. Bannister et al.
CELL RESEARCH (2011)
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
Masoud Vedadi et al.
NATURE CHEMICAL BIOLOGY (2011)
Hypoxia-Induced Down-Regulation of Neprilysin by Histone Modification in Mouse Primary Cortical and Hippocampal Neurons
Zheng Wang et al.
PLOS ONE (2011)
Hypoxia-induced methylation of a pontin chromatin remodeling factor
Jason S. Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
H3K9 Histone Methyltransferase G9a Promotes Lung Cancer Invasion and Metastasis by Silencing the Cell Adhesion Molecule Ep-CAM
Min-Wei Chen et al.
CANCER RESEARCH (2010)
G9a and Glp Methylate Lysine 373 in the Tumor Suppressor p53
Jing Huang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function
Bernhard Lehnertz et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Negative Regulation of Hypoxic Responses via Induced Reptin Methylation
Jason S. Lee et al.
MOLECULAR CELL (2010)
Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4
Eric Metzger et al.
NATURE (2010)
A case study in cross-talk: the histone lysine methyltransferases G9a and GLP
Robert Collins et al.
NUCLEIC ACIDS RESEARCH (2010)
Epigenetic Drugs Can Stimulate Metastasis through Enhanced Expression of the Pro-Metastatic Ezrin Gene
Yanlin Yu et al.
PLOS ONE (2010)
Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors
Shohei Hamada et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin
Mark A. Dawson et al.
NATURE (2009)
Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294
Yanqi Chang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing
Quan Zhao et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells
S. H. Lee et al.
ONCOGENE (2009)
Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells
Pierre-Olivier Esteve et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription
Makoto Tachibana et al.
EMBO JOURNAL (2008)
A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: A Gynecologic Oncology Group study
Susan C. Modesitt et al.
GYNECOLOGIC ONCOLOGY (2008)
Functional analysis of histone methyltransferase G9a in B and T lymphocytes
Lance R. Thomas et al.
JOURNAL OF IMMUNOLOGY (2008)
Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions
Roberto R. Rosato et al.
MOLECULAR CANCER THERAPEUTICS (2008)
Protein lysine methyltransferase G9a acts on non-histone targets
Philipp Rathert et al.
NATURE CHEMICAL BIOLOGY (2008)
A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation
Shima Nakanishi et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes
Guillermo Garcia-Manero et al.
BLOOD (2008)
Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma
C. S. Chim et al.
LEUKEMIA (2007)
Automethylation of G9a and its implication in wider substrate specificity and HP1 binding
Hang Gyeong Chin et al.
NUCLEIC ACIDS RESEARCH (2007)
Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation
Antonis Kirmizis et al.
NATURE (2007)
Pivanex, a histone deacetylase inhibitor, induces changes in BCR-ABL expression and when combined with STI571, acts synergistically in a chronic myelocytic leukemia cell line
E. Rabizadeh et al.
LEUKEMIA RESEARCH (2007)
Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine
Maojun Yang et al.
BIOCHEMISTRY (2007)
Phase I and pharmacokinetic study of vorinostat, A histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies
Suresh S. Ramalingam et al.
CLINICAL CANCER RESEARCH (2007)
Specific inhibition of p300-HAT alters global gene expression and represses HIV replication
K. Mantelingu et al.
CHEMISTRY & BIOLOGY (2007)
High-resolution profiling of histone methylations in the human genome
Artern Barski et al.
CELL (2007)
Functional cooperation between HP1 and DNMT1 mediates gene silencing
Andrea Smallwood et al.
GENES & DEVELOPMENT (2007)
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase
Stefan Kubicek et al.
MOLECULAR CELL (2007)
Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36
Xiaobing Shi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
5-Aza-2′-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3K9 di-methylation levels are linked to tumor suppressor gene reactivation
R. J. Wozniak et al.
ONCOGENE (2007)
Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication
Pierre-Olivier Esteve et al.
GENES & DEVELOPMENT (2006)
Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells
Haobin Chen et al.
CANCER RESEARCH (2006)
Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications
D Nathan et al.
GENES & DEVELOPMENT (2006)
Histone demethylation by a family of JmjC domain-containing proteins
Y Tsukada et al.
NATURE (2006)
G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis
N Feldman et al.
NATURE CELL BIOLOGY (2006)
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
M Stucki et al.
CELL (2005)
The diverse functions of histone lysine methylation
C Martin et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase
XJ Sun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Histone H2B ubiquitylation controls processive methylation but not monomethylation by Dot1 and Set1
MD Shahbazian et al.
MOLECULAR CELL (2005)
WDR5 associates with histone H3 methylated at K4 and is essential for H3K4 methylation and vertebrate development
J Wysocka et al.
CELL (2005)
Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice
H Ryu et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9
M Tachibana et al.
GENES & DEVELOPMENT (2005)
FDA drug approval summary:: Azacitidine (5-azacytidine, Vidaza™) for injectable suspension
E Kaminskas et al.
ONCOLOGIST (2005)
Targeted inhibition of V(D)J recombination by a histone methyltransferase
O Osipovich et al.
NATURE IMMUNOLOGY (2004)
Histone demethylation mediated by the nuclear arnine oxidase homolog LSD1
YJ Shi et al.
CELL (2004)
Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription
K Balasubramanyam et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation
A Lewis et al.
NATURE GENETICS (2004)
Histone H2AX phosphorylation induced by selective photolysis of BrdU-Labeled DNA with UV light: Relation to cell cycle phase
X Huang et al.
CYTOMETRY PART A (2004)
Human PAD4 regulates histone arginine methylation levels via demethylimination
Y Wang et al.
SCIENCE (2004)
Epigenetics in human disease and prospects for epigenetic therapy
G Egger et al.
NATURE (2004)
Histone sumoylation is associated with transcriptional repression
Y Shilo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression
V Anest et al.
NATURE (2003)
MDC1 is a mediator of the mammalian DNA damage checkpoint
GS Stewart et al.
NATURE (2003)
Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains
JC Rice et al.
MOLECULAR CELL (2003)
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8
KW Henry et al.
GENES & DEVELOPMENT (2003)
Active genes are tri-methylated at K4 of histone H3
H Santos-Rosa et al.
NATURE (2002)
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis
M Tachibana et al.
GENES & DEVELOPMENT (2002)
Methylation at arginine 17 of histone H3 is linked to gene activation
UM Bauer et al.
EMBO REPORTS (2002)
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability
AHFM Peters et al.
CELL (2001)
Rb targets histone H3 methylation and HP1 to promoters
SJ Nielsen et al.
NATURE (2001)
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
M Lachner et al.
NATURE (2001)
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
L Jackson-Grusby et al.
NATURE GENETICS (2001)
Regulation of chromatin structure by site-specific histone H3 methyltransferases
S Rea et al.
NATURE (2000)
Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14
WS Lo et al.
MOLECULAR CELL (2000)
The language of covalent histone modifications
BD Strahl et al.
NATURE (2000)
HATs off: Selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF
OD Lau et al.
MOLECULAR CELL (2000)