期刊
FRONTIERS IN IMMUNOLOGY
卷 6, 期 -, 页码 -出版社
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fimmu.2015.00303
关键词
MAIT cells; infection; MR1; bacteria; vitamins
类别
资金
- Cancer Research UK [C399/A17722]
- Medical Research Council
- Radcliffe Department of Medicine, University of Oxford
- MRC [G1000800, MC_UU_12010/1] Funding Source: UKRI
- Cancer Research UK [11331, 17722] Funding Source: researchfish
- Medical Research Council [G1000800, G1000800e, MC_UU_12010/1] Funding Source: researchfish
MR1-restricted mucosal-associated invariant T (MAIT) cells recognize vitamin B metabolites, which are generated by a broad range of bacteria, from Escherichia coli to Mycobacterium tuberculosis and BCG. MAIT cells have been described as innate sensors of infection as they accumulate early in infected tissues. MAIT cells maintain an activated phenotype throughout the course of infections, secrete inflammatory cytokines, and have the potential to directly kill infected cells, playing an important role in shaping the host response. In this review, we will discuss the current knowledge regarding the molecular mechanisms that underline MAIT cells activation in sterile and non-sterile inflammatory conditions.
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