期刊
FRONTIERS IN IMMUNOLOGY
卷 6, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2015.00106
关键词
immune metabolism; macrophages; microglia,Warburg effect; multiple sclerosis; EAE; mitochondria
类别
资金
- National Multiple Sclerosis Society (NMSS) [RG-4001-A1]
- Italian Multiple Sclerosis Foundation (FISM) [RG 2010/R/31]
- FISM [10/12/F14/2011]
- Italian Ministry of Health [GR08/7]
- European Research Council (ERC) [RG 260511-SEM_SEM]
- European Community (EC) [RG 280772-iONE]
- Evelyn Trust [RG 69865]
- Bascule Charitable Trust [RG 75149]
- FEBS long-term fellowship
- MRC [MC_UP_1101/3, MC_UU_12022/6] Funding Source: UKRI
- Medical Research Council [MC_UP_1101/3, MC_UU_12022/6] Funding Source: researchfish
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS). Accumulation of brain damage in progressive MS is partly the result of mononuclear phagocytes (MPs) attacking myelin sheaths in the CNS. Although there is no cure yet for MS, significant advances have been made in the development of disease modifying agents. Unfortunately, most of these drugs fail to reverse established neurological deficits and can have adverse effects. Recent evidence suggests that MPs polarization is accompanied by profound metabolic changes, whereby pro-inflammatory MPs (M1) switch toward glycolysis, whereas anti-inflammatory MPs (M2) become more oxidative. It is therefore possible that reprograming MPs metabolism could affect their function and repress immune cell activation. This mini review describes the metabolic changes underpinning macrophages polarization and anticipates how metabolic re-education of MPs could be used for the treatment of MS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据