期刊
FRONTIERS IN IMMUNOLOGY
卷 6, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2015.00128
关键词
HLA-G; trophoblasts; dendritic cells; IL-10; T regulatory cells; vascular remodeling
类别
资金
- Telethon Italy [TGT11E02]
- Italian Ministry of Health [RF-2011-02346774]
- European grant for European cooperation in science and technology (Action to Focus and Accelerate Cell-based Toleranceinducing Therapies)
- Fondazione Giorgio Pardi, Milan, Italy
Extravillous trophoblasts (EVTs) play a central role in educating maternal leukocytes, endometrial stromal and endothelial cells to generate a receptive decidual microenvironment tailored to accept the semi-allogeneic fetus. HLA-G, a non-classical HLA class I molecule endowed with immune-regulatory functions, is primarily expressed on EVTs lining the placenta and on the naturally occurring tolerogenic dendritic cells, named DC10, which are enriched in the human first trimester decidua. Decidual DC-10 are involved in HLA-G-mediated tolerance at the maternal fetal interface. EVTs not only establish a tolerogenic microenvironment through the interaction with maternal innate and adaptive cells but also orchestrate placenta vascular and tissue remodeling, leading to a successful pregnancy. Here, we discuss the potential implications of the HLA-G-mediated cross-talk among the cells present at the maternal fetal interface, and its role in maintaining a positive relationship between the mother and the fetus.
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