期刊
FRONTIERS IN IMMUNOLOGY
卷 6, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2015.00009
关键词
HLA-G; tumors; viral hepatitis; parasitic disorders; polymorphism
类别
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior [CAPES/COFECUB 653/09]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq] [236754/2012-2, 406594/2013-9, 401641/2013-9, 66036/2013-5, 31/2014, 467157/2014-6]
- Nucleo de Apoio a Pesquisa em Doencas Inflamatorias (NAP-DIN)
Considering that the non-classical HLA-G molecule has well-recognized tolerogenic properties, HLA-G expression is expected to be deleterious when present in tumor cells and in cells chronically infected by viruses, whereas HLA-G expression is expected to be advantageous in autoimmune disorders. The expression of HLA-G on tissue or peripheral blood cells, the levels of soluble HLA-G and polymorphic sites along the gene have been studied in several disorders. In this study, we revised the role of the molecule and polymorphic sites along the HLA-G gene in tumors, viral hepatitis, and parasitic disorders. Overall, several lines of evidence clearly show that the induction of HLA-G expression in tumors has been associated with worse disease outcome and disease spread. In addition, the few studies conducted on hepatitis and parasitic disorders indicate that HLA-G may contribute to disease pathogenesis. Few isolated polymorphic sites, primarily located at the coding or 3' untranslated HLA-G region, have been evaluated in these disorders, and a complete HLA-G typing together with the study of gene regulatory elements may further help on the understanding of the influence of the genetic background on disease susceptibility.
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