期刊
FRONTIERS IN IMMUNOLOGY
卷 6, 期 -, 页码 -出版社
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fimmu.2015.00333
关键词
thymocytes; thymic epithelium; Eph; ephrin; thymic cell seeding
类别
资金
- Spanish Health Ministry [RD06/0010/0003, RD12/0019/0007]
- Spanish Ministry of Economy and Competitiveness [BFU2010-18250, BFU2013-41112-R]
Numerous studies emphasize the relevance of thymocyte thymic epithelial cell (TECs) interactions for the functional maturation of intrathymic T lymphocytes. The tyrosine kinase receptors, Ephs (erythropoietin-producing hepatocyte kinases) and their ligands, ephrins (Eph receptor interaction proteins), are molecules known to be involved in the regulation of numerous biological systems in which cell-to-cell interactions are particularly relevant. In the last years, we and other authors have demonstrated the importance of these molecules in the thymic functions and the T-cell development. In the present report, we review data on the effects of Ephs and ephrins in the functional maturation of both thymic epithelial microenvironment and thymocyte maturation as well as on their role in the lymphoid progenitor recruitment into the thymus.
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