期刊
FRONTIERS IN IMMUNOLOGY
卷 6, 期 -, 页码 1-8出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2015.00138
关键词
autoantibodies; primary immunodeficiencies; autoimmunity; protein microarrays; immunodeficiency
类别
资金
- National Institutes of Health [T32GM007365]
- Donald E. and Delia B. Baxter Foundation
- Ben May Charitable Trust of Mobile, Alabama
- NHLBI Proteomics [HH5N288201000034C]
- NIH [1 U19-A11110491, 1 U19-A1090019, 1 UH2 AR067676, 1 UM2 AR067678]
- Alliance for Lupus Research [21858]
- FP Grant [261]
- European Union [261382]
Autoimmunity is highly coincident with immunodeficiency. In a small but growing number of primary immunodeficiencies, autoantibodies are diagnostic of a given disease and implicated in disease pathogenesis. In order to improve our understanding of the role of autoantibodies in immunodeficiencies and to discover novel autoantibodies, new proteomic tools are needed. Protein microarrays have the ability to screen for reactivity to hundreds to many thousands of unique autoantigens simultaneously on a single chip using minimal serum input. Here, we review different types of protein microarrays and how they can be useful in framing the study of primary and secondary immunodeficiencies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据