期刊
JAMA INTERNAL MEDICINE
卷 173, 期 2, 页码 113-121出版社
AMER MEDICAL ASSOC
DOI: 10.1001/2013.jamainternmed.987
关键词
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资金
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [R34DK080878]
- Scientist Development Grant award from the AHA [0830362N]
- Palo Alto Medical Foundation Research Institute
- Clinical and Translational Science Award for the Stanford Center for Clinical and Translational Education and Research (Spectrum) from the National Center for Research Resources [1UL1 RR025744]
Background: The Diabetes Prevention Program (DPP) lifestyle intervention reduced the incidence of type 2 diabetes mellitus (DM) among high-risk adults by 58%, with weight loss as the dominant predictor. However, it has not been adequately translated into primary care. Methods: We evaluated 2 adapted DPP lifestyle interventions among overweight or obese adults who were recruited from 1 primary care clinic and had pre-DM and/or metabolic syndrome. Participants were randomized to (1) a coach-led group intervention (n=79), (2) a self-directed DVD intervention (n=81), or (3) usual care (n=81). During a 3-month intensive intervention phase, the DPP-based behavioral weight-loss curriculum was delivered by lifestyle coach-led small groups or home-based DVD. During the maintenance phase, participants in both interventions received lifestyle change coaching and support remotely-through secure email within an electronic health record system and the American Heart Association Heart360 website for weight and physical activity goal setting and self-monitoring. The primary outcome was change in body mass index (BMI) (calculated as weight in kilograms divided by height in meters squared) from baseline to 15 months. Results: At baseline, participants had a mean (SD) age of 52.9 (10.6) years and a mean BMI of 32.0 (5.4); 47% were female; 78%, non-Hispanic white; and 17%, Asian/Pacific Islander. At month 15, the mean +/- SE change in BMI from baseline was -2.2 +/- 0.3 in the coach-led group vs -0.9 +/- 0.3 in the usual care group (P<.001) and -1.6 perpendicular to 0.3 in the self-directed group vs usual care (P=.02). The percentages of participants who achieved the 7% DPP-based weight-loss goal were 37.0% (P=.003) and 35.9% (P=.004) in the coach-led and self-directed groups, respectively, vs 14.4% in the usual care group. Both interventions also achieved greater net improvements in waist circumference and fasting plasma glucose level. Conclusion: Proven effective in a primary care setting, the 2 DPP-based lifestyle interventions are readily scalable and exportable with potential for substantial clinical and public health impact. Trial Registration: clinicaltrials. gov Identifier: NCT00842426 JAMA Intern Med. 2013;173(2):113-121. Published online December 10, 2012. doi:10.1001/2013.jamainternmed.987
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