期刊
JAMA DERMATOLOGY
卷 150, 期 6, 页码 593-600出版社
AMER MEDICAL ASSOC
DOI: 10.1001/jamadermatol.2013.10271
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资金
- National Institute of Arthritis Musculoskeletal and Skin Diseases (NIAMS) [R01-AR0056755]
IMPORTANCE Atopic dermatitis (AD) is a common illness of childhood. OBJECTIVE To evaluate the natural history of AD and determine the persistence of symptoms over time. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional and cohort study of a nation-wide long-term registry of children with AD enrolled in the Pediatric Eczema Elective Registry (PEER). MAIN OUTCOMES AND MEASURES Self-reported outcome of whether a child's skin was AD symptom-free for 6 months at 6-month intervals. RESULTS A total of 7157 patients were enrolled in the PEER study for a total of 22 550 person-years. At least 2 years of follow-up were observed for 4248 children and at least 5 years of follow-up were observed for 2416 children. Multiple demographic and exposure variables were associated with more persistent AD. At every age (ie, 2-26 years), more than 80% of PEER participants had symptoms of AD and/or were using medication to treat their AD. It was not until age 20 years that 50% of patients had at least 1 lifetime 6-month symptom-and treatment-free period. CONCLUSIONS AND RELEVANCE Based on this large longitudinal cohort study, symptoms associated with AD seem to persist well into the second decade of a child's life and likely longer. Atopic dermatitis is probably a life-long illness.
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