期刊
FRONTIERS IN IMMUNOLOGY
卷 6, 期 -, 页码 1-26出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2015.00299
关键词
comparative biology; immunology; dendritic cells; monocytes; macrophages; genomic and bio-informatic methods
类别
资金
- Agence Nationale de la Recherche (ANR) PhyloGenDC [ANR-09-BLAN-0073-02]
- European Commission [PITNGA- 2011-289209]
- PhyloGenDC ANR grant
- European Research Council [281225]
- European Research Council (ERC) [281225] Funding Source: European Research Council (ERC)
- Agence Nationale de la Recherche (ANR) [ANR-09-BLAN-0073] Funding Source: Agence Nationale de la Recherche (ANR)
Mononuclear phagocytes are organized in a complex system of ontogenetically and functionally distinct subsets, that has been best described in mouse and to some extent in human. Identification of homologous mononuclear phagocyte subsets in other vertebrate species of biomedical, economic, and environmental interest is needed to improve our knowledge in physiologic and physio-pathologic processes, and to design intervention strategies against a variety of diseases, including zoonotic infections. We developed a streamlined approach combining refined cell sorting and integrated comparative transcriptomics analyses which revealed conservation of the mononuclear phagocyte organization across human, mouse, sheep, pigs and, in some respect, chicken. This strategy should help democratizing the use of omics analyses for the identification and study of cell types across tissues and species. Moreover, we identified conserved gene signatures that enable robust identification and universal definition of these cell types. We identified new evolutionarily conserved gene candidates and gene interaction networks for the molecular regulation of the development or functions of these cell types, as well as conserved surface candidates for refined subset phenotyping throughout species. A phylogenetic analysis revealed that orthologous genes of the conserved signatures exist in teleost fishes and apparently not in Lamprey.
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