期刊
EJNMMI RESEARCH
卷 5, 期 -, 页码 1-10出版社
SPRINGER HEIDELBERG
DOI: 10.1186/s13550-015-0151-x
关键词
Molecular imaging; Activated hepatic stellate cells (aHSCs); Liver fibrosis; Biomarkers; Ligands
资金
- National Natural Science Foundation of China [81430041, 81301266]
- Science & Technology Nova Program of Pearl River of Guangzhou
- Shan Hai Forum Cooperation Projects Foundation of Sun Yat-sen University
- Distinguished Young Scholar Fund of The Third Affiliated Hospital of Sun Yat-sen University
- Medical key Subject Construction Project of Guangzhou
Following injurious stimuli, quiescent hepatic stellate cells (qHSCs) transdifferentiate into activated HSCs (aHSCs). aHSCs play pivotal roles in the onset and progression of liver fibrosis. Therefore, molecular imaging of aHSCs in liver fibrosis will facilitate early diagnosis, prognosis prediction, and instruction and evaluation of aHSC-targeted treatment. To date, several receptors, such as integrin alpha v beta 3, mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF-IIR), collagen type VI receptor (CVIR), platelet-derived growth factor receptor-beta (PDGFR-beta), vimentin, and desmin, have been identified as biomarkers of aHSCs. Corresponding ligands to these receptors have also been developed. This review will discuss strategies for developing aHSC-targeted imaging in liver fibrosis.
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