期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 2, 期 8, 页码 1031-1037出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb21479f
关键词
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资金
- National Basic Research Program of China [2010CB732403]
- National Natural Science Foundation of China [21125524, 21001033]
- Program for New Century Excellent Talents in the University of China [09-0014]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1116]
- National Science Foundation of Fujian Province [2010J06003]
Graphitic-phase carbon nitride (g-C3N4) nanosheets, the newly emerging two-dimensional (2D) layered nanomateriats, have been demonstrated to be promising bioimaging agents due to their high photoluminescence (PL) quantum yields, good biocompatibility and tow toxicity. However, the therapeutic applications of g-C3N4 nanosheets have not been explored until now. In this study, we have proven for the first time that g-C3N4 nanosheets can be used as efficient photosensitizers for photodynamic tumor therapy and as pH-responsive nanocarriers for drug delivery. On one hand, as photosensitizers, g-C3N4 nanosheets are able to generate reactive oxygen species (ROS) and kill cancer cells efficiently under low-intensity light irradiation (20 mW cm(-2)). On the other hand, as nanocarriers, g-C3N4 nanosheets possess an ultrahigh drug-loading capacity owing to their high surface-to-volume ratio. More importantly, g-C3N4 nanosheets loaded with the anticancer drug doxorubicin (DOX) exhibit a pH-responsive release property which is beneficial for the delivery of DOX into cancer cells for chemotherapy. Furthermore, due to their high PL quantum yields, the fluorescent g-C3N4 nanosheets can enable visualization of the delivery. These findings demonstrated the potential of g-C3N4 nanosheets as low-toxic and biocompatible photosensitizers and pH-responsive drug nanocarriers for biomedical applications.
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