期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 2, 期 11, 页码 1454-1463出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb21649g
关键词
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资金
- Deutsche Forschungsgemeinschaft (DFG) [FOR 1738]
- Carl Zeiss foundation
- EC [KBBE-4-265854]
- German Federal Ministry of Economics and Technology (BMWi) [MF110109]
- Center of Medical Optics and Photonics (CEMOP)
- Abbe Center of Photonics (ACP)
- Jena Center of Soft Matter (JCSM) at the Friedrich Schiller University Jena
The water insoluble and photoactive CO releasing molecule dimanganese decacarbonyl (CORM-1) has been non-covalently embedded into poly(L-lactide-co-D/L-lactide) fibers via electrospinning to enable bioavailability and water accessibility of CORM-1. SEM images of the resulting hybrid non-wovens reveal a nanoporous fiber morphology. Slight CO release from the CORM-1 in the electrospinning process induces nanoporosity. IR spectra show the same set of carbonyl bands for the CORM-1 precursor and the non-woven. When the material was exposed to light (365-480 nm), CO release from the incorporated CORM-1 was measured via heterogeneous myoglobin assay, a portable CO electrode and an IR gas cuvette. The CO release rate was wavelength dependent. Irradiation at 365 nm resulted in four times faster release than at 480 nm. 3.4 mu mol of CO per mg non-woven can be generated. Mouse fibroblast 3T3 cells were used to show that the hybrid material is non-toxic in the darkness and strongly photocytotoxic when light is applied.
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