期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 2, 期 17, 页码 2546-2553出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb21348j
关键词
-
资金
- Science and Technology of Shanghai Municipality [11DZ2260300]
- National Natural Science Foundation of China [21274044, 21322405]
- Shanghai Rising-star Program [13QA1401500]
Cationic dendrimers are promising tools in the introduction of nucleic acids into mammalian cells, however, present dendrimer-based gene vectors have modest transfection efficacy and significant toxicity. Here, we synthesized triphenylphosphonium (TPP) conjugated dendrimers and used them as polymeric gene vectors. TPP-conjugated dendrimers can effectively target mitochondria and showed efficient transfection efficacy on HeLa and COS-7 cells with low cytotoxicity on the transfected cells. These materials achieved much higher efficacy than the commercial transfection reagent SuperFect and comparable efficacy with Lipofectamine 2000. This study provides a new insight into the design of efficient and biocompatible gene vectors using dendrimers as scaffolds.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据