期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 2, 期 24, 页码 3839-3848出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb00371c
关键词
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资金
- Ministry of Science and Innovation, Spain [MAT-2010-20001, PIM2010IPO-00646]
- Spanish Research Council (CSIC)
- European Social Fund (ESF) through the JAE-doc program
- Ministerio de Economia y Competitividad, Spain
- Spanish Ministry of Economy and Competitiveness (MINECO) (CONSOLIDER) [CSD2009-00088]
- Ministerio de Ciencia e Innovacion [SAF2011-27863]
- Seventh Framework Programme of the European Commission (EuroNanomed ERA-NET initiative, REBONE) [PI10/02985FIS]
Pseudo-double network hydrogels based on vinylpyrrolidone and anionic methacrylic units were prepared, for the first-time, via a simple one step radical polymerization procedure using thermal or photoinitiation. These networks showed improved mechanical properties, in the hydrated state, compared with their single network cousins and were capable of hosting cells to confluence. Rapid cell detachment can be induced through simple mechanical agitation and the cell sheets can be transplanted easily without the need for a cell superstrate. The results reported in this work suggest that these hydrogels could be used as support systems for cell manipulation and are candidates to compete with the conventionally used thermoresponsive cell platforms based on poly-N-isopropylacrylamide (pNIPAm).
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