期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 2, 期 33, 页码 5461-5467出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb00856a
关键词
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资金
- National Nature Science Foundation of China [21003084, 21375075]
- Student Research Training Program of Qufu Normal University [2013A046]
- Taishan Scholar Foundation of Shandong Province, China
A new type of composite films of graphene oxide (GO) and poly-L-lysine (PLL) have been fabricated for use as bio-scaffold coatings with improved mechanical properties. The morphology, growth and differentiation of mesenchymal stem cells (MSCs) on the GO/PLL composite films have been examined. The results demonstrated that the GO/PLL composite films could not only support the growth of MSCs with a high proliferation rate, but could accelerate the osteogenic differentiation of MSCs, showing strong alkaline phosphatase (ALP) and gene expression. Importantly, the high pre-concentration capacity of the GO/PLL films for osteogenic inducers could play a key role in accelerating the osteogenic differentiation of MSCs through the strong non-covalent binding and electrostatic interaction between them. Moreover, the mild and inexpensive fabrication strategy could be applicable to biomacromolecules including chitosan, gelatin, etc. Therefore, such a kind of composite film could provide a multifunctional and highly biocompatible scaffold coating tailored for potential application in stem cell research.
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