期刊
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
卷 6, 期 2, 页码 184-194出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s13346-015-0233-3
关键词
Osteogenesis; Bone scaffold; Biomaterials; Stem cells; Tissue engineering
资金
- NIH Biomedical Engineering Training Grant
- NSF CAREER [1350554]
- Maryland Stem Cell Research Fund [2014-MSCRFI-0699]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1350554] Funding Source: National Science Foundation
Growth factors are essential orchestrators of the normal bone fracture healing response. For non-union defects, delivery of exogenous growth factors to the injured site significantly improves healing outcomes. However, current clinical methods for scaffold-based growth factor delivery are fairly rudimentary, and there is a need for greater spatial and temporal regulation to increase their in vivo efficacy. Various approaches used to provide spatiotemporal control of growth factor delivery from bone tissue engineering scaffolds include physical entrapment, chemical binding, surface modifications, biomineralization, micro-and nanoparticle encapsulation, and genetically engineered cells. Here, we provide a brief review of these technologies, describing the fundamental mechanisms used to regulate release kinetics. Examples of their use in pre-clinical studies are discussed, and their capacities to provide tunable, growth factor delivery are compared. These advanced scaffold systems have the potential to provide safer, more effective therapies for bone regeneration than the systems currently employed in the clinic.
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