期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 2, 期 44, 页码 7771-7778出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb01391c
关键词
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资金
- National Health and Medical Research Council (NHMRC), Australia
- Australian Research Council
- Australian Postgraduate Award
- NHMRC Career Development Award
- Viertel charitable Foundation, Australia
- Australian Research Council Australian Postdoctoral Fellowship
- NHMRC Career Development Fellowship
- Alfred Deakin Research Fellowship
- Victorian Government's Operational Infrastructure Support Grant
Tissue specific scaffolds formed from minimalist N-fluorenylmethyloxycarbonyl self-assembling peptides (Fmoc-SAPs) have emerged as promising biomaterials due to their ease of synthesis and capacity to self-assemble via simple, non-covalent interactions into complex nanofibrous hydrogels. However, concerns remain over their biocompatibility and cytotoxicity for in vivo applications. Here, we demonstrate that these Fmoc-SAPs are biocompatible in vivo and well suited as a delivery vehicle for cell transplantation. In order to determine the effect of tissue specific parameters, we designed three Fmoc-SAPs containing varying bioactive peptide sequences derived from extracellular matrix proteins, laminin and fibronectin. Fmoc-SAPs delivering cortical neural progenitor cells into the mouse brain display a limited foreign body response, effective functionalization and low cytotoxicity for at least 28 days. These results highlight the suitability of Fmoc-SAPs for improved neural tissue repair through the support of grafted cells and adjacent host parenchyma. Overall, we illustrate that Fmoc-SAPs are easily engineered materials for use as a tool in cell transplantation, where biocompatibility is key to promoting cell survival, enhancing the graft-host interface and attenuation of the inflammatory response for improved tissue repair outcomes.
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