期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 2, 期 38, 页码 6626-6633出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb00717d
关键词
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资金
- Jiangsu Collaborative Innovation Center of Biomedical Functional Materials
- National and Local Joint Engineering Research Center of Biomedical Functional Materials
- Base of Natural Science Foundation of Jiangsu Province of China [BK 20131396]
- Natural Science Foundation of Universities of Jiangsu Province [14KJA150006]
- production, education and research of the prospective joint research project of Jiangsu Province [BY2011109]
Chemiluminescence was used as an excitation light source to construct a universal photoelectrochemical platform based on Mn2+-doped NaYF4:Yb/Er upconversion nanoparticles, which greatly improves the electrochemiluminescence intensity and offers more stable cathodic signals compared to pure NaYF4:Yb/Er NPs. Here, we report for the first time the ECL behaviors of Mn2+-doped NaYF4:Yb/Er NPs, which were synthesized via a facile strategy. Mn2+ doping resulted in a 4-fold ECL intensity enhancement of NaYF4:Yb/Er. The characteristics of Mn2+-doped NaYF4:Yb/Er nanocomposites were obtained using transmission electron microscopy (TEM), energy dispersive X-ray spectrometer (EDS), and fluorescence spectra. After all the results had indicated that NaYF4:Yb/Er upconversion nanoparticles were successfully doped with Mn2+, the electrochemiluminescence platform was built. The as-prepared NaYF4:Yb/Er NPs were rendered water-soluble and then employed as ECL emitters for carcinoembryonic antigen (CEA) determination. The results indicated that the modified electrode can be used to determine CEA without interference from non-specific proteins, with a low detection limit of 5.2 pg mL(-1). The biosensor can also be used for quantification of the CEA concentration in real samples.
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