期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 2, 期 2, 页码 171-180出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb21230k
关键词
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资金
- Korea Healthcare Technology R and D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea [A120942]
- National Research Foundation of Korea
- Ministry of Education, Science, and Technology (MEST) [2012R1A2A2A01017435]
A method for fabrication of nanoscale surface patterns on electrospun polycaprolactone (PCL) fibers and melt-plotted PCL struts was developed. Physical patterns were achieved using selective plasma treatment in the presence of an anodic aluminum oxide (AAO) template (800 nm). The nanoscale-patterned surfaces were evaluated using X-ray photoelectron spectroscopy (XPS) and topological analyses. The roughness (R-a) of the fabricated patterns on the electrospun PCL fiber surfaces was 716 +/- 43 nm, while normally plasma-treated surfaces exhibited relatively low roughness (R-a 126 +/- 13 nm). To evaluate the feasibility of using a microfibrous PCL mat with a nanoscale-roughened surface as a biomedical scaffold, osteoblast-like cells (MG63) were cultured and analyzed using fluorescence analysis (live/dead and 4',6-diamidino-2-phenylindole (DAPI)/phalloidin analyses), alkaline phosphatase (ALP) activity determination, and calcium deposition. The selectively plasma-treated PCL mats exhibited outstanding biological activities, such as cell proliferation and differentiation, compared with untreated PCL fibrous mats (control) and normally plasma-treated fibrous mats.
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