Aggregation induced chirality in a self assembled perylene based hydrogel: application of the intracellular pH measurement

With the aim of controlling helicity of self-assembled fibers, a pair of water soluble perylene derivatives has been designed and synthesized. Intermolecular hydrogen bonding interactions and pi-pi stacking, combined with the effect of molecular chirality, have been found to guide the aggregation that eventually led to gelation in water upon decreasing pH. This work has demonstrated a new paradigm of simple and non-toxic perylene derivatives for biological applications.