期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 1, 期 37, 页码 4828-4833出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb20641f
关键词
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资金
- Australian Research Council [DP110100394]
- UQ
- University of Queensland
Mesoporous silica nanoparticles (MSNs) have emerged as one of the most promising vehicles for potential application in drug delivery. In this paper, we report a novel multifunctional nanocomposite composed of a magnetite nanocrystal core and a mesoporous silica shell (Fe3O4@mSiO(2)), end-capped with pH-stimuli-responsive hydroxyapatite (HAp) nanovalves for pH-responsive drug release. Iron oxide core and mesoporous silica shell nanoparticles were synthesized using a microemulsion method, and were then employed as templates for surface coating of hydroxyapatite. The efficient coating of the natural nontoxic component hydroxyapatite was achieved through a biomimetic mineralization process. The pH-responsive release of the model drug ibuprofen showed that the Fe3O4@mSiO(2)@HAp nanoparticles possessed pH-responsive drug-release functionalities. The dissolution of hydroxyapatite in an acidic environment triggers the release of the loaded drugs in Fe3O4@mSiO(2)@HAp nanoparticles.
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