期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 1, 期 20, 页码 2582-2589出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb20234h
关键词
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资金
- Natural Science Foundation of China [21275027, 21235001, 21075013]
- Program of New Century Excellent Talents in University [NCET-11-0071]
- SRFDP program [20120042110020]
- Fundamental Research Funds for the Central Universities [N110705002, N110405005, N110805001]
beta-FeOOH has shown promise as a new contrast agent in magnetic resonance imaging (MRI), however, sensitive and accurate MR imaging is largely limited by its low transverse relaxivity (r(2)). Herein, for the first time we report in situ growth of beta-FeOOH nanorods onto PEGylated graphene oxide (GO) sheets to produce a nanocomposite, e. g., GO-PEG-beta-FeOOH. This nanocomposite exhibits a record ultra-high transverse relaxivity (r(2)) value of 303.81 mM(-1) s(-1), that is, >60 times higher than those achieved by hitherto reported beta-FeOOH based MRI contrast agents. This well facilitates its practical use as a contrast agent for in vivo MR imaging. PEG on the surface of the GO nanocomposite improved the colloidal stability in aqueous medium. In addition, in vitro cell viability tests demonstrated that GO-PEG-beta-FeOOH has minimal cellular toxicity. GO-PEG-beta-FeOOH has been used for loading doxorubicin hydrochloride (DOX) with a capacity of 1.35 mg mg(-1), which exhibits high efficiency in Hela cell apoptosis. These results indicated that GO-PEG-beta-FeOOH provides an effective alternative to the existing nanoparticle-based contrast agents for non-invasive in vivo MR imaging and cancer therapy.
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