期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 1, 期 45, 页码 6254-6260出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb21197e
关键词
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资金
- University of Nottingham
- Medical Research Council (MRC)
- ERC
- MRC [G0801741, G0601768] Funding Source: UKRI
- Medical Research Council [G0601768, G0801741] Funding Source: researchfish
Colorectal carcinoma (CRC) is the 3rd most common cancer worldwide, thus development of novel therapeutic strategies is imperative. Herein potent, selective dose-dependent antitumor activity of horse spleen apoferritin encapsulated PbS quantum dots (AFt-PbS) against two human-derived colorectal carcinoma cell lines is reported (GI(50) similar to 70 mu g mL(-1)). Following in vitro exposure to AFt-PbS, CRC cells fail to recover proliferative capacity, and undergo apoptosis triggered by the generation of reactive oxygen species (ROS). In stark contrast, the AFt-PbS nanocomposites do not affect the growth and cell cycle of non-tumor human microvessel endothelial HMEC-1 cells (GI(50) > 500 mu g mL(-1)). In vivo, AFt-PbS QDs are well tolerated by mice. Neither adverse health nor behavioral indicators were observed throughout the 15 day study. The photoluminescence of AFt-PbS combined with selective antitumor activity offer potential development of AFt-PbS for simultaneous non-invasive imaging and treatment of malignant tissue.
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