期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 1, 期 8, 页码 1142-1149出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2tb00275b
关键词
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资金
- NSF [DMR-0805179]
- Institute for Critical Technologies and Applied Sciences at Virginia Tech
- Intramural Research Program (IRP) at NINDS/NIH
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [0909065, 1106182] Funding Source: National Science Foundation
Magnetic Block Ionomer Clusters (MBIClusters) with hydrophilic ionic cores and nonionic coronas have been prepared that have ultrahigh transverse NMR relaxivities together with capacities for incorporating high concentrations of polar antibiotic payloads. Magnetite-polymer nanoparticles were assembled by adsorbing the polyacrylate block of an aminofunctional poly(ethylene oxide-b-acrylate) (H2N-PEO-b-PAA) copolymer onto magnetite nanoparticles. The PEO blocks extended into aqueous media to keep the nanoparticles dispersed. Amines at the tips of the H2N-PEO corona were then linked through reaction with a PEO diacrylate oligomer to yield MBIClusters where the metal oxide in the precursor nanoparticles were distinctly separated by the hydrophilic polymer. The intensity average spacing between the magnetite nanoparticles within the clusters was estimated to be similar to 50 nm. These MBIClusters with hydrophilic intra-cluster space had transverse relaxivities (r(2)'s) that increased from 190 to 604 s(-1) mM Fe-1 measured at 1.4 T and 37 degrees C as their average sizes increased. The clusters were loaded with up to similar to 38 wt% of the multi-cationic drug gentamicin. MRI scans focused on the livers of mice demonstrated that these MBIClusters are sensitive contrast agents.
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