期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 1, 期 9, 页码 1304-1315出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2tb00273f
关键词
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Hyperbranched polyglycerols containing terminal alkyne and alkyl bromide groups (CH C-HPG-Br) were first synthesized via propargyl alcohol-initiated ring-opening polymerization (ROP) of glycidol, followed by reaction of 2-bromoisobutyryl bromide (BIBB) with the hydroxyl groups to introduce the atom transfer radical polymerization (ATRP) initiators on HPG. Hydrophobic azido-terminated poly(epsilon-caprolactone) (PCL-N-3), prepared a priori via 2-azidoethanol-initiated ROP of epsilon-caprolactone, was then coupled to the CH C-HPG-Br polymer through a Cu(I)-catalyzed alkyne-azide click reaction. The resultant linear-hyperbranched PCL-click-HPG copolymers were cast by phase inversion in an aqueous medium into microporous membranes of well-defined and uniform pores. Not only could the HPG contents in the PCL-click-HPG copolymers be used to control the pore size and porosity of the resulting membranes, but also the alkyl halide chain-ends of HPG allowed the subsequent functionalization of membrane and pore surfaces. The PCL-click-HPG-b-PMPC membrane was prepared via surface-initiated ATRP of zwitterionic 2-methacryloyloxyethyl phosphorylcholine (MPC) from the PCL-click-HPG membrane and pore surfaces. The PCL-click-HPG-b-PMPC membranes exhibit good antifouling and antibacterial adhesion properties with negligible cytotoxicity effects, making the membranes potentially useful for biomaterials and biomedical applications.
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