期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 1, 期 45, 页码 6283-6290出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb21067g
关键词
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资金
- National Research Council (CONICET)
- University of Buenos Aires UBACYT [20020110100081]
- Agencia Nacional de Investigaciones Cienticas y Tecnicas PICT [2012-1441]
Silica-collagen scaffolds were obtained by covalent binding of an aminosilane to glutaraldehyde fixed collagen hydrogels, rendering a three dimensional network of silicon coated collagen fibrils. When compared to non-silicified collagen, silica containing matrices exhibited a 60 fold increment in the rheological properties. Moreover, acellular degradation by collagenase type I indicated that enzymatic digestion occurred at a slower rate for silica modified hydrogels, hence enabling a controlled degradation of the obtained material. In addition, fibroblastic cells seeded on silicified collagen matrices were able to adhere, proliferate and migrate within the scaffold for over 3 weeks as shown by MTT tests and hematoxylin-eosin staining. These results suggest that the herein described method could be useful in the design of materials for tissue engineering purposes.
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