期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 1, 期 13, 页码 1846-1851出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3tb00037k
关键词
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资金
- Funding Project for Academic Human Resources Development in Institutions of Higher Learning under the Jurisdiction of Beijing Municipality [PHR201007114]
- Scientific Research Common Program of Beijing Municipal Commission of Education [KM20110025007]
- Natural Science Foundation of China [81271639, 20976013]
To improve the magnetic properties and MRI contrast effect of Fe3O4 superparamagnetic nanoparticles (NPs), a series of oleate-capped, Mn-doped MnxFe(1-x)Fe2O4 (x <= 0.4) NPs was prepared via a thermal decomposition method and subsequently assembled into nanoclusters by the carboxylic silane. The effects of Mn doping and clustering on the magnetization, relaxivity and contrast enhancement of the MnxFe(1-x)Fe2O4 (x <= 0.4) NPs were studied. Our results revealed that the MnxFe(1-x)Fe2O4 NPs exhibited the highest saturation magnetization of 82.55 emu g(-1) when x - 0.05. Correspondingly, the assembled MnxFe(1-x)Fe2O4 nanoclusters showed the highest relaxivity value of 528 (Mn + Fe) mM(-1) s(-1) and an enhanced MRI contrast in mouse liver. In addition, the MTT and H&E analysis confirmed that MnxFe(1-x)Fe2O4 nanoclusters were non-toxic. Therefore, the biocompatible Mn0.05Fe(1-0.05)Fe2O4 nanoclusters with superior relaxometric properties hold great potential in serving as a novel MRI nanoprobe.
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