期刊
JOURNAL OF DIABETES RESEARCH
卷 2013, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2013/248563
关键词
-
资金
- Japan Society for the Promotion of Science [24890148]
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Takeda Science Foundation
- Japanese Association of Dialysis Physicians (JADP) [2012-03]
- Kidney Foundation, Japan [JKF13-1]
- Grants-in-Aid for Scientific Research [24890148] Funding Source: KAKEN
Diabetes and insulin resistance can greatly increase microvascular complications of diabetes including diabetic nephropathy (DN). Hyperglycemic control in diabetes is key to preventing the development and progression of DN. However, it is clinically very difficult to achieve normal glucose control in individual diabetic patients. Many factors are known to contribute to the development of DN. These include diet, age, lifestyle, or obesity. Further, inflammatory-or oxidative-stress-induced basis for DN has been gaining interest. Although anti-inflammatory or antioxidant drugs can show benefits in rodent models of DN, negative evidence from large clinical studies indicates that more effective anti-inflammatory and antioxidant drugs need to be studied to clear this question. In addition, our recent report showed that potential endogenous protective factors could decrease inflammation and oxidative stress, showing great promise for the treatment of DN.
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