期刊
JOURNAL OF CANCER
卷 9, 期 18, 页码 3295-3302出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.25691
关键词
Systemic immune-inflammation index; cancer; prognosis; meta-analysis
类别
资金
- Henan Natural Science Foundation [162300410288]
- National Natural Science Foundation [U1204811]
- China Postdoctoral Science special Foundation [2014T70688]
- Youth Innovation Fund of the First Affiliated Hospital of Zhengzhou University [201301]
Systemic immune-inflammation index (SII), on the basis of lymphocyte, neutrophil and platelet counts had been published to be a good prognostic factor in multiple cancers. Nevertheless, the prognostic value of SII in cancer patients remains inconsistent. Therefore, we carried out a meta-analysis to evaluate the prognostic value of SII in these patients with cancer. A total of 22 articles with 7657 patients enrolled in this meta-analysis. The combined result revealed that a high SII was evidently correlated with poor overall survival (OS) (HR=1.69, 95%CI=1.42-2.01, p<0.001), poor time to recurrent (TTR) (HR=1.87, p<0.001), poor progress-free survival (PFS) (HR=1.61, p=0.012), poor cancer-specific survival (CSS) (HR=1.44, p=0.027), poor relapse-free survival (RFS) (HR=1.66, p=0.025) and poor disease-free survival (DFS) (HR=2.70, p<0.001) in patients with cancers. Subgroup analysis indicated that SII over the cutoff value could predict worse overall survival in Hepatocellular carcinoma (p<0.001), Gastric cancer (p=0.005), Esophageal Squamous Cell Carcinoma (p=0.013), Urinary system cancer (p<0.001), Small cell lung cancer (p<0.001), Non-Small cell lung cancer (p<0.001) and Acral Melanoma (p<0.001). The largest effect size was observed in the Hepatocellular carcinoma (HR=2.11). In addition, these associations did not vary significantly by the cutoff value, sample size and ethnicity. Therefore, high SII may be a potential prognostic marker in patients with various cancers and associated with the poor overall outcomes.
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