期刊
JOURNAL OF CANCER
卷 5, 期 2, 页码 125-132出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.8242
关键词
Epithelial-mesenchymal transition; epithelial-myeloid transition; osteomimetic properties of cancer cells; macrophage and platelet traits of cancer cells; common clusters of differentiation between cancer cells and cells of the myeloid lineage
类别
Cancer cells express epithelial markers, and when progressing in malignancy they may express markers of the mesenchymal cell type. Therefore an epithelial-mesenchymal transition of the cancer cells is assumed. However the mesenchymal markers can equally well be interpreted as myeloid markers since they are common in both types of cell lineages. Moreover, cancer cells express multiple specific markers of the myeloid lineages thus giving rise to the hypothesis that the transition of cancer cells may be from epithelial to myeloid cells and not to mesenchymal cells. This interpretation would better explain why cancer cells, often already in their primary cancer site, frequently show properties common to those of macrophages, platelets and pre-/osteoclasts.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据