4.7 Article

A pilot study of temsirolimus and body composition

期刊

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
卷 4, 期 4, 页码 259-265

出版社

WILEY
DOI: 10.1007/s13539-013-0113-y

关键词

Temsirolimus; Body composition; Sarcopenia; Toxicity

资金

  1. NCATS NIH HHS [UL1 TR000371] Funding Source: Medline

向作者/读者索取更多资源

Purpose Body weight and composition play a role in cancer etiology, prognosis, and treatment response. Therefore, we analyzed the weight, body composition changes, and outcome in patients treated with temsirolimus, an mTor inhibitor that has weight loss as one of its side effects. Patients and methods Sixteen patients with advanced solid tumors treated with temsirolimus were studied; body composition was evaluated utilizing computerized tomography images. Sarcopenia was defined as skeletal muscle index lower than 38.5 cm(2)/m(2) for women and 52.4 cm(2)/m(2) for men. Results Five of 16 patients (31 %) were men; median age, 60 years. Forty-four percent (7/16) of patients were sarcopenic. Fatigue, anemia, hyperglycemia, and hyperlipidemia were common. Baseline sarcopenia and body composition did not correlate with worse toxicity or treatment outcome. However, there was a trend for greater loss of adipose area (p= 0.07), fat mass (p= 0.09), and adipose index (p= 0.07) for patients with grade 3 or 4 toxicities versus those with grade 1 and 2 side effects. Conclusion Patients with higher grade toxicities tended to lose more body fat, suggesting a possible end-organ metabolic effect of temsirolimus. These observations merit exploration in a larger cohort of patients.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据