期刊
JOURNAL OF THE AMERICAN HEART ASSOCIATION
卷 2, 期 2, 页码 -出版社
WILEY
DOI: 10.1161/JAHA.113.004978
关键词
aging; cardiovascular disease risk factors; epidemiology; risk score
资金
- National Institute on Aging [AG12975, AG033751]
- National Institute of Diabetes and Digestive and Kidney Diseases [DK60753]
- Center for Aging in Diverse Communities, UCSF, under the Resource Centers for Minority Aging Research program by the National Institute on Aging, National Institutes of Health [P30-AG15272]
- American Heart Association/American Stroke Association/American Brain Foundation
Background-The purpose of this study was to examine the associations of cardiovascular disease (CVD) risk with cognitive decline and incidence of dementia and cognitive impairment but not dementia (CIND) and the role of education as a modifier of these effects. Methods and Results-One thousand one hundred sixteen Mexican American elderly were followed annually in the Sacramento Area Latino Study on Aging. Our sex-specific 10-year CVD risk score included baseline age, systolic blood pressure, total cholesterol, high-density lipoprotein, smoking, body mass index, and diabetes. From adjusted linear mixed models, errors on the Modified Mini-Mental State Exam (3MSE) were annually 0.41% lower for women at the 25th percentile of CVD risk, 0.11% higher at the 50th percentile, and 0.83% higher at the 75th percentile (P value of CVDriskxtime <0.01). In men, 3MSE errors were annually 1.76% lower at the 25th percentile of CVD risk, 0.96% lower at the 50th percentile, and 0.12% higher at the 75th percentile (P value of CVDriskxtime <0.01). From adjusted linear mixed models, the annual decrease in the Spanish and English Verbal Learning Test score was 0.09 points for women at the 25th percentile of CVD risk, 0.10 points at the 50th percentile, and 0.12 points at the 75th percentile (P value of CVDriskxtime = 0.02). From adjusted Cox models in women, compared with having <6 years of education, having 12+ years of education was associated with a 76% lower hazard of dementia/CIND (95% CI, 0.08 to 0.71) at the 25th percentile of CVD risk and with a 45% lower hazard (95% CI, 0.28 to 1.07) at the 75th percentile (P value of CVDriskx education=0.05). Conclusions-CVD risk score may provide a useful tool for identifying individuals at risk for cognitive decline and dementia.
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