期刊
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES
卷 1, 期 4, 页码 298-302出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s12539-009-0048-3
关键词
siRNA; pathogenesis; knockdown; vaccine
The genus flavivirus in the family Flaviviridae consists of many arthropod transmitted human pathogens. siRNA is a novel strategy used for controlling the gene expression of flavivirus. These are 20-25 nucleotide long dsRNA molecules that target genes at expression level. Nine flavivirus genomes were used to in silico identify the siRNA. Twenty three siRNAs were identified in the 5 ' UTR and capsid protein encoding gene from flavivirus. These siRNA can be useful to knockdown the flavivirus and it might also be helpful for constructing live attenuated vaccine.
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