期刊
IMMUNITY & AGEING
卷 9, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1742-4933-9-18
关键词
Cytomegalovirus; Seropositivity; IgG antibody level; Type 2 diabetes; HbA1c; Non-fasting glucose; C-reactive protein; Elderly; Oldest olds
资金
- Netherlands Organisation of Scientific Research (ZonMw)
- Ministry of Health, Welfare, and Sports
- Netherlands Genomics Initiative/Netherlands Organization for scientific research (NGI/NWO) [05040202, 050-060-810 NCHA]
- EU [FP6 036894]
- DFG [Pa 361/14-1]
Background: Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old. Results: CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05). Conclusions: In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据