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Tomas Ganz et al.
ANNUAL REVIEW OF MEDICINE, VOL 62, 2011 (2011)
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Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease
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Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin
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Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 form
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Tocilizumab, a humanized anti-interleukin-6 receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-induced hepcidin production
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Lack of the bone morphogenetic protein BMP6 induces massive iron overload
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BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
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The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin
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Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
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Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
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Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4
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High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
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Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
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Interleukin induces hepcidin expression through STAT3
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Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing
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Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
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Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice
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Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin
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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
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Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
G Papanikolaou et al.
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Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease
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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
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