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Characterizing 5-methylcytosine in the mammalian epitranscriptome

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GENOME BIOLOGY
卷 14, 期 11, 页码 -

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BMC
DOI: 10.1186/gb4143

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资金

  1. MRC [G0801904] Funding Source: UKRI
  2. Cancer Research UK [15181, 16134] Funding Source: researchfish
  3. British Skin Foundation [5010] Funding Source: researchfish
  4. Medical Research Council [G0801904] Funding Source: Medline
  5. Wellcome Trust [079249] Funding Source: Medline

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The post-transcriptional modification 5-methylcytosine (m(5)C) occurs in a wide range of coding and non-coding RNAs. We describe transcriptome-wide approaches to capture the global m(5)C RNA methylome. We also discuss the potential functions of m(5)C in RNA and compare them to 6-methyladenosine modifications.

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