期刊
GENOME BIOLOGY
卷 14, 期 7, 页码 -出版社
BMC
DOI: 10.1186/gb-2013-14-7-r79
关键词
PAR-CLIP; microRNA; generative model; EM algorithm
资金
- BMBF (NGFN-Plus) [0IGS080I]
- MRC [GI002523]
- NHSBT [WPII-05]
- Swiss Cancer League [KFS 02477-08-2009]
PARma is a complete data analysis software for AGO-PAR-CLIP experiments to identify target sites of microRNAs as well as the microRNA binding to these sites. It integrates specific characteristics of the experiments into a generative model. The model and a novel pattern discovery tool are iteratively applied to data to estimate seed activity probabilities, cluster confidence scores and to assign the most probable microRNA. Based on differential PAR-CLIP analysis and comparison to RIP-Chip data, we show that PARma is more accurate than existing approaches. PARma is available from http://www.bio.ifi.lmu.de/PARma
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