期刊
GENOME BIOLOGY
卷 13, 期 11, 页码 -出版社
BMC
DOI: 10.1186/gb-2012-13-11-r111
关键词
-
资金
- Israel Science Foundation
- Israel Ministry of Science
Genome-scale metabolic network reconstructions are considered a key step in quantifying the genotypephenotype relationship. We present a novel gap-filling approach, MetabolIc Reconstruction via functionAl GEnomics (MIRAGE), which identifies missing network reactions by integrating metabolic flux analysis and functional genomics data. MIRAGE's performance is demonstrated on the reconstruction of metabolic network models of E. coli and Synechocystis sp. and validated via existing networks for these species. Then, it is applied to reconstruct genome-scale metabolic network models for 36 sequenced cyanobacteria amenable for constraintbased modeling analysis and specifically for metabolic engineering. The reconstructed network models are supplied via standard SBML files.
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