期刊
GENOME BIOLOGY
卷 12, 期 10, 页码 -出版社
BMC
DOI: 10.1186/gb-2011-12-10-r105
关键词
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资金
- NIH/NCI [CA135877]
- NIH [P30CA006973]
- NSF [0342111]
- Direct For Mathematical & Physical Scien
- Division Of Mathematical Sciences [0342111] Funding Source: National Science Foundation
We introduce and evaluate data analysis methods to interpret simultaneous measurement of multiple genomic features made on the same biological samples. Our tools use gene sets to provide an interpretable common scale for diverse genomic information. We show we can detect genetic effects, although they may act through different mechanisms in different samples, and show we can discover and validate important disease-related gene sets that would not be discovered by analyzing each data type individually.
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